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pentobarbital will reduce the level or impact of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or result of eltrombopag by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep track of.
pentobarbital will decrease the level or influence of pimavanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Prevent coadministration if possible. Observe for lessened pimavanserin efficacy. An increase in pimavanserin dosage can be necessary.
pentobarbital will reduce the extent or impact of amiodarone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will lessen the extent or result of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
Contraindications to pentobarbital use involve prior hypersensitivity reactions to drug use or barbiturate class use. Barbiturates can cause hypersensitivity reactions by immediate histamine release or immunoglobulin E (IgE)–mediated mechanisms and may lead to anaphylaxis.
pentobarbital will reduce the extent or influence of acalabrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will reduce the level or result of alprazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
benzhydrocodone/acetaminophen and pentobarbital the two increase sedation. Prevent or Use Alternate Drug. Restrict use to individuals for whom option treatment method options are insufficient
pentobarbital will lower the extent or outcome of rabeprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
Cessation of benzodiazepines or other CNS depressants is desired in most cases. Sometimes, monitoring at a better degree of more info look after tapering CNS depressants could be suitable. In Many others, slowly tapering a patient off of the prescribed benzodiazepine or other CNS depressant or lowering to the lowest helpful dose could possibly be proper.
pentobarbital will lessen the extent or influence of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to a decrease in fentanyl plasma concentrations, insufficient efficacy or, potentially, growth of the withdrawal syndrome in a affected person who's got designed Actual physical dependence to fentanyl.
This drug may possibly interfere Together with the absorption of orally administered griseofulvin, decreasing its blood ranges; effects of blood amount reduction unknown; preferable to prevent concomitant administration of these medicines
pentobarbital will lessen the level or outcome of finasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.